Dr. Steward’s Blog

What is Hemp?

  • Cannabis Sativa with less than 0.3% THC
  • Mostly grown for fiber
  • We grow for cannabinoids, terpenes, flavonoids
  • Oil, seed, stem, flower, extract
  • Full, complete, isolate, broad
  • Organically grown
  • Concentrator

Common cannabinoids

  • THC (tetrahydrocannabinol)
  • THCA (tetrahydrocannabinolic acid)
  • CBD (cannabidiol)
  • CBDA (cannabidiolic acid)
  • CBN (cannabinol)
  • CBG (cannabigerol)
  • CBC (cannabichromene)
  • CBL (cannabicyclol)
  • CBV (cannabivarin)
  • THCV (tetrahydrocannabivarin)
  • CBDV (cannabidivarin)
  • CBCV (cannabichromevarin)
  • CBGV (cannabigerovarin)
  • CBGM (cannabigerol monomethyl ether)
  • CBE (cannabielsoin)
  • CBT (cannabicitran)

Common Terpenes

  • α-Pinene
  • β-Pinene
  • Myrcene
  • α-Phellandrene
  • Δ3-Carene
  • α-Terpinene
  • β-Phellandrene
  • Limonene
  • cis-Ocimene
  • Terpinolene
  • β-Caryophyllene
  • α-Guaiene
  • Humulene
  • δ-Guaiene
  • Elemene
  • Guaiol
  • γ-Eudesmol
  • β-Eudesmol
  • Agarospirol
  • Bulnesol
  • α-Bisabolol

Flavonoids

  • Understudied
  • Pharmacologically active
  • synergistic

The Endocannabinoid System.

https://healer.com/the-endocannabinoid-system/

  • Naturally occurring
  • Extensive
  • 1990’s
  • Anadanmide, AEA, 2-AG
  • Receptors lacking in brain stem (careful about dogs)

Endocannabinoid Deficiency

https://echoconnection.org/clinical-endocannabinoid-deficiency/

  • Cannabis use disorder
  • Micro dosing
  • Triad IBS, Fibromyalgia, Migraine

Routes of Administration

  • Inhaled (Smoke, Vaporize, Magic Breath)
  • Sublingual
  • Oral
  • Topical
  • Suppository
  • Injected

Dosing

  • Dosing curve
  • Micro
  • Standard
  • Macro

Cannabis Drug interactions

  • P450 cyp 3a4 2c9 2c19
  • Azoles
  • Clobazem

Opioids and Cannabis

Cannabis and anxiety

Cannabis and cancer

  • Apoptosis vs. necrosis
  • Decrease cellular reproduction
  • Decrease angiogenesis
  • Decrease metastasis
  • Augment chemo therapy
  • Treat side effects of chemotherapy
  • Prevent neurotoxicity
  • Actinic

What happens in states when they adopt liberal cannabis laws?

  • Decreased death rate prescription drugs
  • Prescription drug use decreases
Michael Steward M.D.

I am a licensed physician, but not your physician. The information provided here is for education only, not advice, recommendation or prescription.